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Antabuse (Disulfiram)

Background: Used since 1951

Category: Alcohol-abuse deterrent

IMPORTANT WARNING:

Never give disulfiram to a patient in a state of intoxication of alcohol or without the complete knowledge of the patient. The patient should not take disulfiram for at least 12 hours having drunk it. A reaction can occur since until 2 weeks after disulfiram been stopped.

Why is this medication prescribed?

Disulfiram is used to treat chronic alcoholism. It causes unpleasant effects when even small quantities of alcohol are used. These effects include fact to make leave of the face, splitting headache, nausea, vomiting, pain of case, weakness, blurred vision, mental confusion, fact to sweat, suffocation, by sniffing difficulty and anxiety. These effects begin about 10 minutes after alcohol enters the body and last for 1 hour or more. Disulfiram is not a remedy for alcoholism, but discourages drink it. This treatment is sometimes prescribed for other uses; ask your doctor or chemist for more information.

How should this medicine be used?

Disulfiram enters bars to take by the mouth. It should be taken one time a day. Follow directions on your tab of prescript carefully and ask your doctor or chemist to explain any party which you do not understand. Take disulfiram exactly as aimed. Do not take it more or less or often take it more than prescribed by your doctor. If you cannot swallow bars, crush them and blend the treatment with water, coffee, tea, milk, soda, or juice of fruit.

What special precautions should I follow?

Before taking disulfiram,

• tell your doctor and pharmacist if you are allergic to disulfiram or any other drugs.
  
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially amitriptyline (Elavil), anticoagulants ('blood thinners') such as warfarin (Coumadin), isoniazid, metronidazole (Flagyl), phenytoin (Dilantin), any nonprescription drugs that might contain alcohol, and vitamins.
  
• tell your doctor if you have or have ever had diabetes, thyroid disease, epilepsy, brain damage, or kidney or liver disease.
  
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking disulfiram, call your doctor.
  
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking disulfiram.
  
• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.

What special dietary instructions should I follow?

Do not drink alcoholic drinks (by including the wine, beer and the treatments which contain some alcohol as the cough mixture) by taking disulfiram, during the period of 12 hours before you take your first dose and for several weeks after fact to stop medicament. Avoid sauces, vinegars and all food and drinks containing some alcohol.

What should I do if I forget a dose?

Take the dose missed as soon as you remember it. However, if it is almost the time for the following dose, skip the missed dose and continue your program of regular proportion. Do not take double dose to compensate for one missed.

What side effects can this medication cause?

Although side effects from disulfiram are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

• skin rash
  
• acne
  
• mild headache
  
• drowsiness
  
• tiredness
  
• impotence
  
• metallic taste or garlic-like taste in the mouth
  

If you experience any of the following symptoms, call your doctor immediately:

• excessive tiredness
  
• weakness
  
• lack of energy
  
• loss of appetitie
  
• upset stomach
  
• vomiting
  
• yellowness of the skin or eyes
  
• dark urine

What storage conditions are needed for this medicine?

Keep this treatment in the container in which it entered, firmly closed and inaccessible of the children. Keep it in the temperature of room and far from the warmth of excess and humidity (not in the bathroom). Throw any treatment unthinkingly which is old-fashioned or necessarier. Dialogue to your chemist of the necessary disposition of your treatment.

What other information should I know?

Keep all dates with your doctor and laboratory. Your doctor will order certain tests of laboratory to prove your answer in disulfiram. Always carry an identity card declaring that you take disulfiram and point out the doctor or the institution to be contacted in an emergency. If you need an identity card, ask your chemist or doctor how to accept that.

Do not get into contact with or sniff fumes of painting, comb finer, varnish, shellac and other products containing some alcohol. The caution of financial year by applying products containing alcohol (by eg, lotions after - shave, waters of Cologne and alcohol) in your skin. These products, in the combination with disulfiram, can cause splitting headache, nausea, local blush, or itches. Before fact to use a product containing alcohol, assess it by applying some to a small region of your skin for 1-2 hours. If no blush, itches, or superfluous effects occur, you can use the product definitely.

What to Think About

Disulfiram should not be taken in the course of 24 hours to drink some alcohol. He stays in the blood system since until 2 weeks after the last dose.

Symptoms can develop during this time if the person drinks some alcohol. People with the problems of use of alcohol can ask the friends or the members of family to help them to take disulfiram as aimed until they feel confident that they can take it all alone.

Liver function tests may need to be done before and during the time a person is taking disulfiram.

People who take disulfiram cannot take the treatment or use substances which contain some alcohol (as cough mixtures, liquid treatments containing some alcohol, baths of mouth and wine vinegars). It will cause the same effects which occur when alcohol is taken. Disulfiram communicates with several other treatments. Ask your professional of health if the treatments which you take could communicate with it.

People who take the medicine of antiseizure (as phenytoin, for instance, Dilantin) should use disulfiram with caution as medicines can not react reciprocally definitely.

People who have to go through long distance for medical care can not be able of taking disulfiram. He can cause a strict reaction if the person drinks some alcohol and he or she will need urgent medical care to stop reaction.